Group leader: Dr. Pawel Golik, professor at the University of Warsaw, Faculty of Biology, Institute of Genetics and Biotechnology.
Project funded by the TEAM grant from the Foundation for Polish Science.
The major aims of the project are:
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To study the co-evolution of nuclear-encoded mitochondrial gene-expression factors and the mitochondrial genome in different yeast species. -
To analyze the mechanisms of mitochondrial RNA processing in model yeast S. cerevisiae through assigning functions to putative nuclear-encoded factors involved in the process and studying their genetic and physical interactions, and to identify and dissect the mechanisms of those steps in the mitochondrial RNA processing, that remain unknown.
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To propose yeast models for human disorders caused by mitochondrial mutations and defects in nucleo-mitochondrial interactions.
These goals will be achieved by combining classical and molecular yeast genetics, molecular biology and biochemistry and theoretical evolutionary biology and bioinformatics.
